Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 53, Issue 4, Pages 453-455Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.53.453
Keywords
marine-derived fungus; Myrothecium sp.; myrothenone; 6-n-pentyl-alpha-pyrone; trichodenone A; tyrosinase inhibitory activity
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New 3-amino-5-ethenylcyclopentenones, myrothenones A (4) and B (5), were isolated together with known 6-n-pentyl-alpha-pyrone (1), trichodenone A (2), and cyclonerodiol (3) from the marine algicolous fungus of genus of Myrothecium. The structure and absolute stereochemistry of the new compounds were established by spectral interpretation and X-ray analysis. Compounds I and 4 exhibited a tyrosinase inhibitory activity with IC50 value of 0.8 and 6.6 mu m, respectively, which are more active than kojic acid (IC50, 7.7 mu m) currently being used as a functional personal-care compound.
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