Journal
JOURNAL OF NATURAL PRODUCTS
Volume 68, Issue 4, Pages 577-580Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np0496688
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Funding
- NCI NIH HHS [U19-CA-52956] Funding Source: Medline
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Fractionation of the chloroform-soluble extract of the leaves and twigs of Calyptranthes pallens, collected from an experimental plot in a hardwood forest of southern Florida, using a hormone-dependent human prostate carcinoma (LNCaP) tumor cell line, led to the isolation of a phloroglucinol derivative with a novel carbon skeleton, pallenic acid (1), and a new triterpenoid, 3 beta-hydroxy-18 alpha,19 alpha-urs-20-en-28-oic acid (2). The known compound methylene-bis-aspidinol (3) was selectively active against the human oral epidermoid carcinoma (KB) cell line. Several known compounds of the ellagic acid, lignan, phloroglucinol, sterol, and triterpene types were also obtained in the present investigation.
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