Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 8, Issue 2, Pages 154-160Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2005.02.009
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Funding
- NIGMS NIH HHS [R01 GM063790-03, GM63790] Funding Source: Medline
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GATC sequences in Escherichia coli DNA are methylated at the adenine residue by DNA adenine methyltransferase (DamMT). These methylated residues and/or the level of DamMT can influence cellular functions such as gene transcription, DNA mismatch repair, initiation of chromosome replication and nucleoid structure. In certain bacteria, unlike E coli, DamMT is essential for viability perhaps owing to its role in chromosome replication. DamMT has also been implicated as a virulence factor in bacterial pathogenesis. The origin and phylogeny of DamMT, based on sequenced genomes, has been deduced.
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