Journal
THROMBOSIS AND HAEMOSTASIS
Volume 93, Issue 4, Pages 655-660Publisher
GEORG THIEME VERLAG KG
DOI: 10.1160/TH04-12-0838
Keywords
tissue-type plasminogen activator; plasminogen; central nervous system; LTP; excitotoxicity
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Funding
- NINDS NIH HHS [R01 NS050537] Funding Source: Medline
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Although conventionally associated with fibrin clot degradation, recent work has uncovered new functions for the tissue plasminogen activator (tPA)/plasminogen cascade in central nervous system physiology and pathology. This extracellular proteolytic cascade has been shown to have roles in learning and memory, stress, neuronal degeneration, addiction and Alzheimer's disease. The current review considers the different ways tPA functions in the brain.
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