Journal
JOURNAL OF NEUROVIROLOGY
Volume 11, Issue 2, Pages 129-137Publisher
SPRINGER
DOI: 10.1080/13550280590922793
Keywords
axon; dendrite; nervous system; olfactory receptor neuron; prion; virus
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Olfactory receptor neurons are unique in their anatomical structure and function. Each neuron is directly exposed to the external environment at the site of its dendritic nerve terminals where it is exposed to macromolecules. These molecules can be incorporated into by olfactory receptor neurons and transported transsynaptically to the central nervous system. Certain neurotropic pathogens such as herpes simplex virus and Borna disease virus make use of this physiological mechanism to invade the brain. Here the authors review the olfactory transmission of infectious agents and the resulting hazards to human and animal health.
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