Journal
JOURNAL OF FLUORINE CHEMISTRY
Volume 126, Issue 4, Pages 491-498Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2004.11.010
Keywords
nucleophilic trifluoromethylation; trifluoromethyl carbinols; aldehydes; ketones; imines
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The simple thermal addition product of N,N-dimethyltrimethylsilylamine with 2,2,2-trifluoroacetophenone provides a shelf-stable reagent for nucleophilic trifluoromethylation of both the carbonyl and the imine group. (c) 2004 Elsevier B.V. All rights reserved.
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