Journal
BRAIN AND LANGUAGE
Volume 93, Issue 1, Pages 95-105Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandl.2004.08.004
Keywords
aphasia; TMS; naming; stroke rehabilitation
Funding
- NCRR NIH HHS [M01 RR01032, K24 RRO18875] Funding Source: Medline
- NIDCD NIH HHS [R01 DC005672-03, R01 DC05672, R01 DC005672-02, R01 DC005672-01] Funding Source: Medline
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Functional imaging studies with nonfluent aphasia patients have observed over-activation in right (R) language homologues. This may represent a maladaptive strategy; suppression may result in language improvement. We applied slow, 1 Hz repetitive transcranial magnetic stimulation (rTMS) to an anterior portion of R Broca's homologue daily, for 10 days in four aphasia patients who were 5-11 years poststroke. Significant improvement was observed in picture naming at 2 months post-rTMS, with lasting benefit at 8 months in three patients. This preliminary, open trial suggests that rTMS may provide a novel treatment approach for aphasia by possibly modulating the distributed, bi-hemispheric language network. Published by Elsevier Inc.
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