Journal
CLINICAL IMMUNOLOGY
Volume 115, Issue 1, Pages 19-25Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2005.02.010
Keywords
costimulation; T cells; c-Maf; NFATc1; collagen-induced arthritis; IL-17
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Proper T cell activation and function are regulated by the innate immune system, importantly through positive and negative costimulatory molecules of the B7 superfamily. Inducible costimulator (ICOS) is expressed on T cells after T cell activation. A ligand for ICOS, B7h (also known as B7RP-1), is expressed on B cells and induced in nonlymphoid tissues by TNF-alpha. The wide distribution of B7h may play essential roles in different phases and types of immune function. In this review, we summarize the latest data about inducible costimulator and its receptor and their roles in regulation of immune and autoimmune responses. (c) 2005 Elsevier Inc. All rights reserved.
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