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The multitude of targets for the immune system and drug therapy in the fungal cell wall

Journal

MICROBES AND INFECTION
Volume 7, Issue 4, Pages 789-798

Publisher

ELSEVIER
DOI: 10.1016/j.micinf.2005.03.002

Keywords

antifungal therapy; antimicrobial antibodies; fungal cell walls; unfamiliar components

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Recent studies on fungi revealed that several cytosolic and membrane components migrate to the cell wall together with secreted proteins and biosynthetic polysaccharides to build a dynamic immunoreactive structure. New aspects of fungal cell wall assembly and biosynthesis, focusing on the potential of glycolipids, melanin, heat-shock proteins, historic and surface antigens as targets of drugs and antifungal anti-bodies are discussed. (c) 2005 Elsevier SAS. All rights reserved.

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