Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 16, Issue 2, Pages 205-213Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2005.02.003
Keywords
FGF; skeletal development; craniosynostosis; achondroplasia; receptor tyrosine kinase
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Funding
- NICHD NIH HHS [P01 HD039952, P01 HD039952-05, HD39952] Funding Source: Medline
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Mutations in fibroblast growth factor receptors (Fgfrs) are the etiology of many craniosynostosis and chondrodysplasia syndromes in humans. The phenotypes associated with these human syndromes and the phenotypes resulting from targeted mutagenesis in the mouse have defined essential roles for FGF signaling in both endochondral and intramembranous bone development. In this review, I will focus on the role of FGF signaling in chondrocytes and osteoblasts and how FGFs regulate the growth and development of endochondral bone. (c) 2005 Elsevier Ltd. All rights reserved.
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