Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 161, Issue 1-2, Pages 1-11Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2004.11.016
Keywords
neurosphere; human; spinal cord; forebrain; MHC; co-stimulatory molecules
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The ability to expand human neural precursor cells in vitro offers new possibilities for future cell therapies. However, concern over immunologically based rejection of in vitro-expanded human neural cells confounds their use as donor cells. Here, we demonstrate that the expression of human leukocyte antigen (HLA) class I and II molecules, but not the co-stimulatory proteins CD40, CD80 and CD86, substantially increase during expansion of neurospheres. Furthermore, peripheral lymphocytes were unresponsive when co-cultured with in vitro-expanded neural cells. Taken together, these results suggest a low immunogenicity of these cultured human neural cells despite HLA incompatibility and high HLA expression. (C) 2004 Elsevier B.V All rights reserved.
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