Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 129, Issue 2, Pages 248-256Publisher
WILEY
DOI: 10.1111/j.1365-2141.2005.05443.x
Keywords
CXC-chemokines; CXCRs; multiple myeloma; plasma cells; tumour progression
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Bone marrow endothelial cells (EC) from patients with multiple myeloma (MM) Were found to express and secrete higher amounts of the CXC-chemokines CXCL8/interleukin (IL)-8, CXCL11/interferon-inducible T-cell alpha chemoattractant (I-TAC), CXCL12/stromal cell-derived factor (SDF)-1 alpha, and CCL2/monocyte chemotactic protein(MCP)-1 than EC from human umbilical vein (HUVEC), considered as a healthy counterpart. Paired plasma cells and several MM cell lines expressed cognate receptors of each chemokine to a variable extent. When cells were exposed to chemokines, CXCL8/IL-8 and CXCL12/SDF-1 alpha stimulated their proliferation and all chemokines stimulated cell chemotaxis. It is suggested that angiogenesis also favours MM progression through the release of CXC-chemokines.
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