Journal
GENESIS
Volume 41, Issue 4, Pages 154-159Publisher
WILEY
DOI: 10.1002/gene.20106
Keywords
alpha-Synuclein; Drosophila; Parkin; Parkinson's disease; negative geotaxis
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Funding
- NINDS NIH HHS [F31 NS41852-02] Funding Source: Medline
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Previously published reports have suggested that misexpression of alpha-Synuclein in the Drosophila central nervous system causes neurodegeneration and progressive age-dependent locomotor dysfunction Similar to pathologic and clinical manifestations of Parkinson's disease. The number of dopaminergic (DA) neurons in these studies was assessed using immunohistochemistry with an anti-tyrosine hydroxylase antibody on sequential paraffin sections of fly brains. In contrast, we do not observe any DA cell loss in a-Synuclein expressing fly brains when using whole-mount immunohistochemistry as an assay. Our results suggest that the DA cell loss observed with misexpression of alpha-Synuclein is not fully penetrant under a variety of experimental conditions and that this may complicate interpretation of such experiments. (c) 2005 Wiley-Liss, Inc.
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