Journal
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
Volume 13, Issue 2, Pages 127-133Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/106689690501300201
Keywords
colorectal cancer; polymorphism; tissue microarray; thymidylate synthase
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Response of colorectal cancers to 5-fluorouracil appears to be influenced by differences in thymidylate synthase (TS) expression. To explore the relationship between TS 5' genotype and expression, we analyzed paired tumor and normal tissue from 87 colorectal cancers by tissue microarray. A trend to an association between TS genotype and expression was observed, but the correlation was weak. Although the 2R homozygote was preferentially associated with TS expression (p < 0.03), no relationship was observed for the 3R homozygote (p=1.0). The relationship between 5' TS genotype and TS expression is not simple. For clinical trials incorporating TS status, detection of TS expression in tumors by immunohistochemistry must still remain the benchmark over genotype.
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