Journal
CLINICAL NEUROLOGY AND NEUROSURGERY
Volume 107, Issue 3, Pages 187-190Publisher
ELSEVIER
DOI: 10.1016/j.clineuro.2004.07.013
Keywords
tacrolimus; myasthenia gravis; prednisone; cyclosporin
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Thirteen patients with myasthenia gravis, unresponsive to prednisone and cyclosporin after thymectomy, received KF506 (tacrolimus) for 12 months, at starting doses of 0.1 mg/kg per day b.i.d. and then adjusted to achieve plasma concentrations between 7 and 8 ng/mL. The doses of prednisone were progressively reduced and finally discontinued. Anti-acetylcholine antibodies and myasthenia gravis score for disease severity decreased significantly and muscular strength increased by 37%. All patients achieved pharmacological remission, 11 were asymptomatic and two had minimal weakness of eyelid closure. Tacrolimus was well tolerated and appears a suitable approach after unsuccessful treatment with conventional immunosuppressants in patients with disabling myasthenia. (c) 2004 Elsevier B.V. All rights reserved.
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