Journal
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Volume 61, Issue 4, Pages 387-390Publisher
BLACKWELL PUBLISHING LTD
DOI: 10.1111/j.1365-3083.2005.01586.x
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Mechanisms induced by tryptophan (trp) catabolism are important in the regulation of both normal and pathogenetic immune responses. The key enzyme is indoleamine-pyrrole 2,3-dioxygenase ( EC 1.13-11.42) (IDO) which converts trp to kynurenine (kyn), the main toxic metabolite. It is known that interferon-gamma (IFN-γ) is able to activate IDO. We wanted to analyse whether the strength of this mechanism would be under genetic control. To this end, we analysed the IFN-γ +874(T/A) genotypes, which are known to have an effect on IFN-γ production, of 309 healthy blood donors and correlated these to the levels of trp and kyn in their blood. The data obtained demonstrate that the presence of the high producer T allele was associated with increased IDO activity (i.e. elevated kyn and kyn/trp levels), but this effect was observed only in females. These data show that trp catabolism is genetically controlled by the IFN-γ gene and may thus be operative in those disease conditions associated with the polymorphisms of the IFN-γ gene.
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