Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 19, Issue 4, Pages 287-301Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328205048044
Keywords
porogen filler; acrylic bone cement; biodegradable polymers; poly(amino acids); trans-4-hydroxy-L-proline; polyamide of trans-4-hydroxy-L-proline
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The aim of this study was to synthesize on a larger scale, an experimental polyamide based on an amino acid of traps-4-hydroxy-L-proline. The polyamide of traps-4-hydroxy-L-prohne has been used as porogen filler (i.e., a hydrophilic pore generating material) in nondegradable acrylic bone cement. In in vitro studies, this hydrophilic filling component has been shown to form porosity within the acrylic bone cement in an aqueous environment. The formation of in situ porosity in the acrylic polymer matrix is believed to improve the fixation between the cement and the living bone. Namely, a porous structure can support bone ingrowth and strengthen the mechanical connection between the acrylic bone cement and the bone. The monomer, traps-4-hydroxy-L-proline methyl ester, was prepared from traps-4-hydroxy-L-proline by means of two steps, and the monomer was then polymerized to polyamide of traps-4-hydroxy-L-proline. The polymerization was carried out using a melt polycondensation method. The molecular weights (M-v) of the produced polyamides were between 1800 and 3600. The products were characterized by FTIR and H-1-NMR spectroscopy.
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