Journal
PEDIATRIC BLOOD & CANCER
Volume 44, Issue 4, Pages 348-357Publisher
WILEY
DOI: 10.1002/pbc.20219
Keywords
high dose melphalan; randomised trial; stage 3 and 4 neuroblastoma; survival; toxicity
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Background. High dose myeloalblative chemotherapy (megatherapy), with haematopoietic stem cell support, is now widely used to consolidate response to induction chemotherapy in patients with advanced neuroblastoma. Procedure. In this study (European Neuroblastoma Study Group, ENSG1), the value of melphalan myeloalblative megatherapy was evaluated in a randomised, multi-centre trial. Between 1982 and 1985, 167 children with stages IV and III neuroblastoma (123 stage IV>1 year old at diagnosis and 44 stage III and stage IV from 6 to 12 months old at diagnosis) were treated with oncovin, cisplatin, epipodophyllotoxin, and cyclophosphamide (OPEC) induction chemotherapy every 3 weeks. After surgical excision of Primary tumour. the 90 patients (69% of the total) who achieved complete response (CR) or good partial response (GPR) were eligible for randomisation either to high dose melphalan (180 ing per square meter) with autologous bone marrow Support or to nofurther treatment. Results. Sixty-five (72%) of eligible children were actually randomised and 21 of these patients were Surviving at time of this analysis, with median follow-up from randomisation of 14.3 years. Five year event-free survival (EFS) was 38% (95% confidence interval (CI) 21-540%) in the melphalan-treated group and 27% (95% CI 12-42%) in the nomelphalan group. This difference was not statistically significant (P=0.08, log rank test) but for the 48 randomised stage IV patients aged >1 year at diagnosis outcome was significantly better in the melphalan-treated group-5 year EFS 33% versus 179% (P=0.01, log rank test). Conclusions. In this trial, high dose melphalan improved the length of EFS and overall survival of children with stage IV neuroblastoma >1 year of age who achieved CR or GPR after OPEC induction therapy and Surgery. Multi-agent myeloalblative regimens are now widely used as consolidation therapy for children with stage IV disease and in those with other disease stages when the MYCN gene copy number in tumour cells is amplified. Because they are more toxic, complex, and costly these combination megatherapy regimens should be compared with single agent melphalan in randomised clinical trials. (C) 2004 Wiley-Liss, Inc.
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