Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 20, Issue 4, Pages 682-692Publisher
WILEY-BLACKWELL
DOI: 10.1359/JBMR.041201
Keywords
osteonectin; extracellular matrix; fish skeleton; PTH-related peptide; scales
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The skeleton is the main source of osteonectin mRNA in adults of the seawater teleost sea bream Sparus auratus. It is expressed by cells forming the basement membrane of calcifying tissue indicating that, as in mammals, it may play a role in osteoblast differentiation. PTHrP induced downregulation of osteonectin mRNA in vitro in scales, a mineralizing tissue with bone-like metabolism. This indicates a means to redirect calcium to activities such as vitellogenesis when this ion is in high demand.
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