Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 21, Issue 4, Pages 325-333Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/jmri.20272
Keywords
HIV; dementia; magnetic resonance spectroscopy; multicenter; technique
Funding
- NCRR NIH HHS [RR00522] Funding Source: Medline
- NIMH NIH HHS [MH61438] Funding Source: Medline
- NINDS NIH HHS [NS32228, NS26643] Funding Source: Medline
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Purpose: To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia. Materials and Methods: Twenty HIV-positive (HIV+) individuals underwent SV-MRS (TE 35 msec) and MRSI (TE 280 msec). Results were stratified according to serostatus, dementia severity, psychomotor speed performance, and functional impairment. Results: HIV+ individuals with psychomotor slowing had an increased myoinositol/creatine (mI/Cr) ratio (0.63 vs. 0.45) in the frontal white matter using SV-MRS and an increased choline (Cho)/Cr ratio (1.88 vs. 1.41) in the mesial frontal gray matter using MRSI compared to HIV+ individuals without psychomotor slowing. Using MRSI, subjects with HIV dementia also had a decreased N-acetyl aspartate (NAA)/Cho ratio (1.55 vs. 2.53) compared to HIV+ individuals without cognitive impairment in the mesial frontal gray matter. Both techniques detected metabolite ratio abnormalities associated with abnormal functional performance. Conclusion: SV-MRS and MRSI offer complementary roles in evaluating individuals with HIV dementia. Short TE SV-MRS measures mI, which may be elevated in early HIV dementia, whereas MRSI provides wider spatial coverage to examine specific regional changes. (c) 2005 Wiley-Liss, Inc.
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