Journal
TRENDS IN GENETICS
Volume 21, Issue 4, Pages 219-226Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2005.02.010
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Funding
- NIGMS NIH HHS [R01 GM068042] Funding Source: Medline
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Classical studies in genetics involving aneuploidy and ploidy comparisons and sex-determination mechanisms indicated a balance phenomenon such that changes of individual chromosomal dosage altered the phenotype more dramatically than changes in ploidy. Recent evidence suggests that a major contributor to this balance is the behavior of molecular complexes that function in various regulatory processes affecting gene expression. In this article, we discuss the potential contribution of regulatory balance to the control of quantitative traits, hybrid vigor, genome evolution and post-zygotic speciation mechanisms.
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