Journal
TRENDS IN IMMUNOLOGY
Volume 26, Issue 4, Pages 208-214Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2005.02.002
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Funding
- FIC NIH HHS [TW006831] Funding Source: Medline
- NIDDK NIH HHS [DK58066] Funding Source: Medline
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Src-family kinases and Syk tyrosine kinases have crucial roles in multiple leukocyte intracellular signaling pathways. In immunoreceptor-related pathways, these enzymes work together sequentially, with Src-family kinases phosphorylating specific protein substrates, which in turn recruit and activate Syk. Recent evidence indicates that several non-immunoreceptors also use Src-family kinases and Syk in this same fashion. In leukocyte integrin signaling, the interaction between the kinases is more complex, where they appear to act in a sequential manner but the mechanisms by which they are activated remain poorly defined. Elucidating the regulation of these tyrosine kinase-based signaling pathways in leukocytes remains an important goal in understanding how immune cells respond to the multitude of activating agents they encounter.
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