Journal
SEMINARS IN IMMUNOLOGY
Volume 17, Issue 2, Pages 167-172Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2005.01.007
Keywords
epigenetic regulation; polycomb group protein; V(D)J recombination; histone modification; lymphocyte development
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Funding
- NIAID NIH HHS [5-R01-AI050867, 5-R01-AI053545] Funding Source: Medline
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Gene expression, differentiation and the specialized function of various cell types are controlled epigenetically by post-translational histone modifications. These modifications establish a histone code that is recognized by various regulatory proteins, thereby creating a stable pattern of gene expression. The focus of this review is to discuss how the chromatin modifications regulate immunoglobulin gene rearrangement and B cell differentiation. (c) 2005 Elsevier Ltd. All rights reserved.
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