Journal
IUBMB LIFE
Volume 57, Issue 4-5, Pages 347-353Publisher
WILEY
DOI: 10.1080/15216540500154920
Keywords
apoptosis; cathepsins; cysteine proteases; lysosomes; papain-like enzymes; peptidases; structure
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Among the variety of proteolytic enzymes enormous progress has been seen recently in our understanding of lysosomal cysteine proteases, also known as cysteine cathepsins. These enzymes play a crucial role in diverse biological processes in physiological and pathological states, including genetic diseases. In the present review, their properties and structural features that are important to an understanding of their biological function are presented. Special emphasis is given to the newly discovered role of lysosomal cathepsins in apoptotic pathways.
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