Journal
CEREBRAL CORTEX
Volume 15, Issue 4, Pages 403-408Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhh143
Keywords
degradation; latency; senescent monkeys; visual information processing; visual cortex
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Funding
- NIA NIH HHS [R01-AG17922] Funding Source: Medline
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Senescence in monkeys results in a degradation of the functional properties of cortical cells as well as prolonged hyperactivity. We have now compared the spontaneous and visually evoked activity levels, as well as the visual response latencies of cells in cortical areas V1 and V2 of young and very old monkeys. We found that V1 cells within layer 4 exhibit normal latencies. In contrast, in other parts of V1 and throughout V2 hyperactivity in old monkeys is accompanied by dramatic delays in both the intracortical and intercortical transfer of information. Extrastriate cortex (area V2) is affected more severely than striate cortex (V1). Delayed information processing in cerebral cortex should contribute to the declines in cortical function that accompany old age.
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