Journal
JOURNAL OF IMMUNOLOGY
Volume 174, Issue 7, Pages 3912-3919Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.174.7.3912
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Analyses of V gamma-J gamma rearrangements producing the most commonly expressed TCR gamma chains in over 200 gamma delta TCR+ thymocytes; showed that assembly of TCR gamma V-region genes display properties of allelic exclusion. Moreover, introduction of functionally rearranged TCR gamma and delta transgenes results in a profound inhibition of endogenous TCR gamma rearrangements in progenitor cells. The extent of TCR gamma rearrangements in these cells is best explained by a model in which initiation of TCR gamma rearrangements at both alleles is asymmetric, occurs at different frequencies depending on the V or J segments involved, and is terminated upon production of a functional gamma delta TCR. Approximately 10% of the cells studied contained two functional TCR gamma chains involving different V and J gamma gene segments, thus defining a certain degree of isotypic inclusion. However, these cells are isotypically excluded at the level of cell surface expression possibly due to pairing restrictions between different TCR gamma and 5 chains.
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