Journal
IUBMB LIFE
Volume 67, Issue 7, Pages 472-481Publisher
WILEY-BLACKWELL
DOI: 10.1002/iub.1395
Keywords
groucho; transducin-like enhancer of split (TLE); development; corepressor; transcription factor; homeobox genes
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Funding
- Indian Council of Medical Research (ICMR) Junior Research Fellowship
- Council for Scientific and Industrial Research (CSIR) Junior Research Fellowship
- Wellcome Trust/DBT India Alliance Intermediate fellowship
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Corepressors are proteins that cannot bind DNA directly but repress transcription by interacting with partner proteins. The Groucho/Transducin-Like Enhancer of Split (TLE) are a conserved family of corepressor proteins present in animals ranging from invertebrates such as Drosophila to vertebrates such as mice and humans. Groucho/TLE proteins perform important functions throughout the life span of animals, interacting with several pathways and regulating fundamental processes such as metabolism. However, these proteins have especially crucial functions in animal development, where they are required in multiple tissues in a temporally regulated manner. In this review, we summarize the functions of the Groucho/TLE proteins during animal development, emphasizing on specific tissues where they play essential roles. (C) 2015
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