Journal
IUBMB LIFE
Volume 67, Issue 9, Pages 687-693Publisher
WILEY
DOI: 10.1002/iub.1426
Keywords
cancer stem cells; metabolism; Warburg effect
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Funding
- Associazione Italiana Ricerca Cancro (AIRC), Milan, Italy
- Fondazione CariPaRo, Padova, Italy
- Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR), Rome, Italy
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Cancer stem cells (CSCs) are a sub-population of quiescent cells endowed with self-renewal properties that can sustain the malignant behavior of the tumor mass giving rise to more differentiated cancer cells. For this reason, the specific killing of CSCs represents one of the most important challenges of the modern molecular oncology. However, their particular resistance to traditional chemotherapy and radiotherapy imposes a thorough understanding of their biological and biochemical features. The metabolic peculiarities of CSCs may be a therapeutic and diagnostic opportunity in cancer research. In this review, we summarize the most significant discoveries on the metabolism of CSCs describing and critically analyzing the studies supporting either glycolysis or mitochondrial oxidative phosphorylation as a primary source of energy for CSCs. (c) 2015 IUBMB Life, 67(9):687-693, 2015
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