Journal
TRENDS IN NEUROSCIENCES
Volume 28, Issue 4, Pages 202-208Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2005.02.001
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Funding
- NHLBI NIH HHS [HL63290] Funding Source: Medline
- NIA NIH HHS [AG023084] Funding Source: Medline
- NINDS NIH HHS [NS34467] Funding Source: Medline
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In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings indicate that neurovascular dysfunction contributes to cognitive decline and neurodegeneration in AD. Here, I propose the neurovascular hypothesis of AD, suggesting that faulty clearance of amyloid 0 peptide (A beta) across the blood-brain barrier (BBB), aberrant angiogenesis and senescence of the cerebrovascular system could initiate neurovascular uncoupling, vessel regression, brain hypoperfusion and neurovascular inflammation. Ultimately, this would lead to BBB compromise, to chemical imbalance in the neuronal environment and to synaptic and neuronal dysfunction, injury and loss. Based on the neurovascular hypothesis, I suggest an array of new potential therapeutic approaches that could be developed for AD, to enhance AD clearance and neurovascular repair, and to protect the neurovascular unit from divergent inducers of injury and apoptosis.
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