Journal
SEMINARS IN CANCER BIOLOGY
Volume 15, Issue 2, Pages 113-120Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2004.08.004
Keywords
field cancerization; multistep; secondary cancer; squamous; stem cell
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Recent molecular pathology studies in head and neck cancer support a carcinogenesis model in which the development of a field with genetically altered cells plays a central role. This preneoplastic field is of monoclonal origin and expands non-invasively superseding normal epithelium. Clonal divergence and selection within the field ultimately leads to the development of cancer. These fields can be large (over 7 cm diameter) and are often not visible for the surgeon explaining that they may remain after resection of the primary tumor. when not removed, a field is an important risk factor for secondary cancer. (C) 2004 Elsevier Ltd. All rights reserved.
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