Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 20, Issue 4, Pages 635-643Publisher
AMER SOC BONE & MINERAL RES
DOI: 10.1359/JBMR.041204
Keywords
beta-arrestin; PTH; knockout; bone architecture; bone remodeling
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Funding
- NCRR NIH HHS [S10 RR017868] Funding Source: Medline
- NIAMS NIH HHS [R55 AR049265, R01 AR049265, AR049265] Funding Source: Medline
- NIDDK NIH HHS [P30 DK057521, P30 DK57521] Funding Source: Medline
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Cytoplasmic arrestins regulate PTH signaling in vitro. We show that female beta-arrestin2(-/-) mice have decreased bone mass and altered bone architecture. The effects of intermittent PTH administration on bone microarchitecture differed in beta-arrestin2(-/-) and wildtype mice. These data indicate that arrestin-mediated regulation of intracellular signaling contributes to the differential effects of PTH at endosteal and periosteal bone surfaces.
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