Journal
IUBMB LIFE
Volume 67, Issue 12, Pages 923-927Publisher
WILEY
DOI: 10.1002/iub.1453
Keywords
biomarkers; psoriatic arthritis; microRNAs
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Funding
- Henry Ford Health System Start-up Grant for the Immunology Program
- Chinese Nature Science Foundation [81473681]
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Psoriasis is an immune-mediated skin disease which affects 2-4% of the worldwide population. Approximately 20-30% of patients with psoriasis develop psoriatic arthritis (PsA), a frequently destructive and disabling condition. As skin manifestations precede joint symptoms in nearly all patients with PsA, identification of biomarkers for early prediction of joint damage is an important clinical need. Because not all patients with PsA respond to treatment in the same fashion, identification of biomarkers capable of predicting therapeutic response is also imperative. Here, we review existing literature and discuss current investigations to identify potential biomarkers for PsA disease activity, with particular emphasis on microRNAs as novel markers of interest. Serum (soluble) biomarkers, peripheral osteoclast precursor as cellular biomarkers, and genetic loci associated with skin and joint disease are also reviewed. (c) 2015 IUBMB Life, 67(12):923-927, 2015
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