Journal
TETRAHEDRON-ASYMMETRY
Volume 16, Issue 7, Pages 1289-1294Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2005.02.016
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Metal catalysed addition of diboranes to vinylarenes produces the desired 1,2-bis(boronate)ester and mono(boronate)esters as by-products. Their relative rate is a sensitive function between the nature of the catalytic system and the electronic effects of the substrate, that influences the mechanistic steps of the catalytic cycle. However, asymmetry is only induced as moderate enantiomeric excess values, providing an enantioface differentiation, between the bis- and mono(boronate)esters. Alternatively, the method based on the catalytic asymmetric dihydroboration/oxidation of alkynes as diphenyl acetylene can provide 1,2-diphenyl-1,2-ethanediol (hydrobenzoin) with a selectivity of 68% mainly as the erythro isomer. (c) 2005 Elsevier Ltd. All rights reserved.
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