Journal
TETRAHEDRON-ASYMMETRY
Volume 16, Issue 7, Pages 1377-1383Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2005.02.005
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The domino Michael-aldol reaction of 1,3-diketones with MVK in the presence of L-proline furnished highly substituted cyclohexanones in a regio- and stereocontrolled manner. When the reaction was performed in NMP, high yields (up to 93%) and enantioselectivities up to 80% were observed. (c) 2005 Elsevier Ltd. All rights reserved.
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