Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 48, Issue 7, Pages 2274-2277Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm049035q
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Melanin concentrating hormone (MCH) is involved in regulation of food intake and energy homeostasis. Antagonists of the MCH receptor are expected to affect food intake and weight gain, making MCH-R1 an attractive target for obesity treatment. Herein, we report the discovery of a novel, orally active series of MCH-R1 antagonists that exhibit in vivo efficacy in rodent obesity models.
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