Journal
FEBS LETTERS
Volume 579, Issue 10, Pages 2203-2207Publisher
WILEY
DOI: 10.1016/j.febslet.2005.03.015
Keywords
flavoenzyme; amine oxidase; KIAA0601; historic methylation; chromatin remodelling
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Lysine-specific historic demethylase 1(LSD1) is a very recently discovered enzyme which specifically removes methyl groups from Lys4 of historic 3. We have addressed the functional properties of the protein demonstrating that histone demethylation involves the flavin-catalysed oxidation of the methylated lysine. The nature of the substrate that acts as the electron acceptor required to complete the catalytic cycle was investigated. LSD1 converts oxygen to hydrogen peroxide although this reactivity is not as pronounced as that of other flavin-dependent oxidases. Our findings raise the possibility that in vivo LSD1 might not necessarily function as an oxidase, but it might use alternative electron acceptors. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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