Journal
FEBS LETTERS
Volume 579, Issue 10, Pages 2166-2170Publisher
WILEY
DOI: 10.1016/j.febslet.2005.03.009
Keywords
sodium channel; sodium current; subthreshold current; sensory neuron; biolistic transfection
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The Na(v)1.6 voltage-gated sodium channel has been implicated in the generation of resurgent currents in cerebellar Purkinje neurons. Our data show that resurgent sodium currents are produced by some large diameter dorsal root ganglion (DRG) neurons from wild-type mice, but not from Na(v)1.6-null mice; small DRG neurons do not produce resurgent currents. Many, but not all, DRG neurons transfected with Na(v)1.6 produce resurgent currents. These results demonstrate for the first time the intrinsic ability of Na(v)1.6 to produce a resurgent current, and also show that cell background is critical in permitting the generation of these currents. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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