Journal
ORGANIC LETTERS
Volume 7, Issue 8, Pages 1517-1520Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol0501727
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Funding
- NIGMS NIH HHS [GM56414, 5 T32 GM08349] Funding Source: Medline
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[GRAPHICS] We have evaluated the effects of microwave irradiation on the solid-phase synthesis of beta-peptides. Sequences designed to adopt the 14-helix, especially those containing the structure-promoting residue trans-2-aminocyclohexanecarboxylic acid (ACHC), suffer from poor synthetic efficiency under standard SPPS conditions. A comparison of microwave and conventional heating shows that both provide excellent synthetic results for shorter sequences; however, we identify a clear benefit from microwave irradiation for longer beta-peptides.
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