Journal
JOURNAL OF IMMUNOLOGY
Volume 174, Issue 8, Pages 4606-4612Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.174.8.4606
Keywords
-
Categories
Funding
- NIAID NIH HHS [AI52257, AI32751] Funding Source: Medline
- NIAMS NIH HHS [AR32103, AR39555] Funding Source: Medline
Ask authors/readers for more resources
Among T cell subsets, gamma delta T cells uniquely display an Ag receptor-based tissue distribution, but what defines their preferential homing and homeostasis is unknown. To address this question, we studied the resources that control gamma delta T cell homeostasis in secondary lymphoid organs. We found that gamma delta and alpha beta T cells are controlled by partially overlapping resources, because acute homeostatic proliferation of gamma delta T cells was inhibited by an intact alpha beta T cell compartment, and both populations were dependent on IL-7 and IL-15. Significantly, to undergo acute homeostatic proliferation, gamma delta T cells also required their own depletion. Thus, gamma delta T cell homeostasis is maintained by trophic cytokines commonly used by other types of lymphoid cells, as well as by additional, as yet unidentified, gamma delta-specific factors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available