Development of headspace solid-phase microextraction-gas chromatography method for the determination of solvent residues in edible oils and pharmaceuticals

The application of headspace solid-phase microextraction for isolation and enrichment of solvent residues from oils and pharmaceuticals is discussed. The optimal parameters for isolation and preconcentration of common process solvents (hexane, benzene, toluene and selected chloroderivatives of hydrocarbons) were established. Four fiber types (100 mu m polydimethylsiloxane (PDMS), 75 mu m Carboxen-PDMS, 65 mu m PDMS-divinylbenzene and 85 mu m polyacrylate) were evaluated to choose the most efficient coating, able to absorb the greatest amount of analytes. GC-flame ionization detection (FID) and GC-electron-capture detection systems were used for quantitative and qualitative analysis, adequately to the appropriate group of the analytes. For all compounds the limit of detection (LOD), linearity, dynamic range, repeatability and intermediate precision were estimated. (c) 2004 Elsevier B.V. All rights reserved.