Journal
SCIENCE
Volume 308, Issue 5720, Pages 381-385Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1107573
Keywords
-
Categories
Funding
- NICHD NIH HHS [R01HD28315] Funding Source: Medline
- NIGMS NIH HHS [T32GM07240] Funding Source: Medline
Ask authors/readers for more resources
We used wounded Drosophila embryos to define an evolutionarily conserved pathway for repairing the epidermal surface barrier. This pathway includes a wound response enhancer from the Ddc gene that requires grainy head (grh) function and binding sites for the Grh transcription factor. At the signaling level, tyrosine kinase and extracellular signal-regulated kinase (ERK) activities are induced in epidermal cells near wounds, and activated ERK is required for a robust wound response. The conservation of this Grh-dependent pathway suggests that the repair of insect cuticle and mammal skin is controlled by an ancient, shared control system for constructing and heating the animal body surface barrier.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available