Journal
ANALYTICAL CHEMISTRY
Volume 77, Issue 8, Pages 2381-2385Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac050109v
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Funding
- NCI NIH HHS [P01CA84203] Funding Source: Medline
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We report surface-enhanced Raman scattering (SERS) studies on indocyanine green (ICG) on colloidal silver and gold and demonstrate a novel optical probe for applications in living cells. In addition to its own detection by the characteristic ICG SERS signatures, the ICG gold nanoprobe delivers spatially localized chemical information from its biological environment by employing SERS in the local optical fields of the gold nanoparticles. The probe offers the potential to increase the spectral specificity and selectivity of current chemical characterization approaches of living cells and biomaterials based on vibrational information.
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