Journal
CANCER
Volume 103, Issue 8, Pages 1551-1560Publisher
WILEY-BLACKWELL
DOI: 10.1002/cncr.20947
Keywords
anticancer drug; apoptosis; autophagy; cell death
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Over the past two decades, the role of apoptosis in the cytotoxicity of anticancer drugs has become clear. Apoptosis may occur via a death receptor-dependent (extrinsic) or independent (intrinsic or mitochondrial) pathway. Mitochondria play a central role in cell death in response to DNA damage, and mediate the interaction(s) of various cytoplasmic organelles, including the endoplasmic reticulum, Golgi apparatus, and lysosomes. The mitochondrial pathway of cell death is mediated by Bcl-2 family proteins, a group of antiapoptotic and proapoptotic proteins that regulate the passage of small molecules, such as cytochrome c, Smac/Diablo, and apoptosis-inducing factor, which activates caspase cascades, through the mitochondrial transition pore. In addition, apoptosis call induce autophagic cell death via crosstalk between the two pathways upon treatment with anticancer drugs. The current review focused oil recent advances surrounding the mechanism(s) of cell death induced by anticancer agents and discussed potential molecular targets for enhancing the chemotherapeutic effect(s) of anticancer agents. (c) 2005 American Cancer Society.
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