Journal
GENES & DEVELOPMENT
Volume 19, Issue 8, Pages 891-896Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1301805
Keywords
transcription factor MTF-1; metal response elements; metallothioneins; Ctr1B; copper load; copper depletion
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Funding
- NIGMS NIH HHS [GM62555, R01 GM062555] Funding Source: Medline
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From insects to mammals, metallothionein genes are induced in response to heavy metal load by the transcription factor MTF-1, which binds to short DNA sequence motifs, termed metal response elements (MREs). Here we describe a novel and seemingly paradoxical role for MTF-1 in Drosophila in that it also mediates transcriptional activation of Ctr1B, a copper importer, upon copper depletion. Activation depends on the same type of MRE motifs in the upstream region of the Ctr1B gene as are normally required for metal induction. Thus, a single transcription factor, MTF-1, plays a direct role in both copper detoxification and acquisition by inducing the expression of metallothioneins and of a copper importer, respectively.
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