Journal
ONCOGENE
Volume 24, Issue 17, Pages 2776-2786Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1208613
Keywords
cyclin E; Cdk; cell cycle; tumorigenesis
Funding
- NCI NIH HHS [R01CA102742, R01CA84069] Funding Source: Medline
- NHLBI NIH HHS [K08HL073670] Funding Source: Medline
Ask authors/readers for more resources
Cyclin E- Cdk2 has long been considered an essential and master regulator of progression through G1 phase of the cell cycle. Although recent mouse models have prompted a rethinking of cyclin E function in mammals, it remains clear that cyclin E impacts upon many processes central to cell division. Normal cells maintain strict control of cyclin E activity, and this is commonly disrupted in cancer cells. Moreover, cyclin E deregulation is thought to play a fundamental role in tumorigenesis. In this review, we discuss the regulation and functions of cyclin E in normal and neoplastic mammalian cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available