Journal
ONCOGENE
Volume 24, Issue 17, Pages 2877-2898Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1208608
Keywords
mouse embryo; development; cell cycle
Funding
- NCI NIH HHS [R01 CA085296] Funding Source: Medline
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Mice likely represent the most- studied mammalian organism, except for humans. Genetic engineering in embryonic stem cells has allowed derivation of mouse strains lacking particular cell cycle proteins. Analyses of these mutant mice, and cells derived from them, facilitated the studies of the functions of cell cycle apparatus at the organismal and cellular levels. In this review, we give some background about the cell cycle progression during mouse development. We next discuss some insights about in vivo functions of the cell cycle proteins, gleaned from mouse knockout experiments. Our text is meant to provide examples of the recent experiments, rather than to supply an extensive and complete list.
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