Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 48, Issue 8, Pages 3045-3050Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm049147h
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Funding
- NIAID NIH HHS [N01-AI-85347, AI-48521] Funding Source: Medline
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Novel strategies are required to combat pox virus infections, whether caused by escape of viruses such as monkeypox from indigenous areas or intentional release of smallpox. Anti-smallpox drugs with a unique mode of antiviral action, inhibition of transcription termination, were known but not therapeutically useful. Using a combinatorial method, variants of the basic isatin-beta-thiosemicarbazone structure were prepared and examined for cytotoxicity and antiviral activity in vaccinia virus- and cowpox virus-infected human cells. Potent and much more selective N-aminomethyl-isatin-beta-thiosemicarbazones were discovered.
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