Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 329, Issue 4, Pages 1300-1305Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2005.02.114
Keywords
superoxide detoxification; oxygen metabolism; rubredoxin; neelaredoxin; superoxide reductase
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Archaeoglobus fulgidus neelaredoxin (Nlr) is an electron donor: superoxide oxidoreductase. The reaction of superoxide with reduced Nlr is almost diffusion-limited, but the overall efficiency for detoxifying superoxide in vivo depends on the rate of reduction of Nlr by electron donors. Here, we report the purification and characterization of the two type I rubredoxins from A. fulgidus (AF0880 and AF1349) and show that they act as efficient electron donors for neelaredoxin, in vitro, with a second-order rate constant of 10(7) M-1 s(-1) at 10 degrees C and PH 7.2. (c) 2005 Elsevier Inc. All rights reserved.
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