Journal
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Volume -, Issue 8, Pages 1482-1486Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.200400727
Keywords
chemical nucleases; phosphazenes; pendant polymers; copper complexes; phosphate ester hydrolysis; heterogeneous catalysis
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This study describes nucleolytic activity of a copper-metalated, multisite-coordinating, hybrid polymer CPPL-Cu under oxidative conditions. Rapid relaxation of supercoiled plasmid DNA was observed and mechanistic probing by chemical and enzymatic assays revealed involvement of single-oxygen-derived reactive species. The heterogeneous nature of the catalyst allowed a facile recycling of the artificial nuclease. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005).
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