Journal
TETRAHEDRON
Volume 61, Issue 17, Pages 4313-4321Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2005.02.023
Keywords
alpha-galactosyl epitopes; one-pot synthesis; glycosylations; oligosaccharides; xenotransplantation
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Xenotransplantations from pig to human are rapidly rejected because of the interaction between alpha-Gal epitopes carried by the graft and natural antibodies (anti-Gal antibodies) present in the blood of the recipient. This paper describes a three-component one-pot synthesis of three alpha-Gal related oligosaccharides with minimal protecting group manipulations in a very short period of time. (c) 2005 Elsevier Ltd. All rights reserved.
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